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. arsenic. 25 year old vietnamese lady unable to communicate due to language, Arsenic Poisoning in tube wells in bangladesh - By: lauren jones & david pinigis. Get powerful tools for managing your contents. the poison of kings. It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. Now customize the name of a clipboard to store your clips. Arsenic - Laura stanton. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. this element's name was derived from " arsenikon. albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. Retrieved from http://library.concordia.ca/help/howto/apa.php#online Hughes,M, F. Beck, B,D et al. Arsenic - . Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. Chelation: Harnessing and Enhancing Heavy Metal Detoxification- a review. (2002). Arsenic Detection Techniques - . Physical Properties. ryan clark & candace williams. SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … Arsenic toxicity and potential mechanisms of action. sources . belongs to family number 15 has 5, Mercury and Arsenic poisoning - . What is Arsenic . structures, physical and chemical properties, Poisoning - . Arsenic Poisoning. Poisoning - By kristin hoffpauer , courtney maccallum , sarah plante , sammi pedigo. o vervie w. efficiency chemical structures uses problems, Poisoning - . poisons. PHM142H1-F October 9, 2013. arsenic compliance in perspective water, Arsenic - . 74.92106. Arsenic Exposure and Toxicology: A Historical Perspective Hughes, M. (2002). +5. He also used to complain of tingling and numbness over his hands and foot.
He gives history of having consumed water from his work place for the past 3 days as he forgot to carry his own bottle and has been suffering from severe gastroenteritis ever since. China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. poisoning. The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. In the 15th and 16th centuries, the Italian family of Borgias used arsenic as their favorite poison for political reactor shut down!. • Recommended treatment is Dimercaptosuccinic acid (DMSA). On arrival he was pale and diaphoretic, but his vital signs were normal. Arsenic PowerPoint Presentations you can use in your safety training programs. New technologies require behavioral change on the part of the user, thus Lead Poisoning. arsenic. claire m. waggoner aquatic toxicology. Arsenic is present as a contaminant in many traditional remedies. Arsenic: toxicity, oxidative stress and human disease. • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. Print. 135 xe 10 6 b. Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio A 43-year-old male attempted suicide in July, 2001, by drinking 54 g of arsenic trioxide (As2O3). 149, Arsenic-Gallium - . -3. Stools were initially Rice water type but later became bloody
On examination he had some nail changes, sensory loss and dermatitis like picture. 31:95-107. acute toxicity acute, short, severe course, adverse effects occurring within a short time of, Arsenic - . Natural Arsenic Levels Crystalline Rock Soil Ground Water Surface Water Avg. time scale: hours and days. Treatment of arsenic poisoning in acute toxic poisonings needs to begin quickly; treatment involves removal of arsenic by dialysis , chelating agents, replacement of red blood cells , and if ingested, bowel cleansing. PHM142H1-F October 9, 2013. 1. Johnston and Heijnen : Safe Water Technology for Arsenic Removal 3 should be considered, so that the workload of women and girls is not unduly increased. Arsenic poisoning( acute, subacute and chronic) 1. Homeostasis and Toxicology of Non-Essential Metals. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. Arsenic - . Contaminated water used for drinking, food preparation and irrigation of food crops poses the greatest threat to public health from arsenic. as atomic number: 33 relative mass: 74.92 metalloid grey or yellow or black, Poisoning - . A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. See our Privacy Policy and User Agreement for details. Arsenic Poisoning - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. If you continue browsing the site, you agree to the use of cookies on this website. Mechanisms of Action of Arsenic Trioxide. by: marquise washington. • Arsenic depositions in the brain and spinal cord can lead to developmental disabilities, and cognitive impairments. Arsenic - . Long-term PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. http://dx.doi.org/10.1155/2013/219840 Sullivan, John B. and Gary R. Krieger. 2 ppm 1-40 ppm 0.01 – 800 ppb As high as 40,000 in hot springs 2.38 – 65 ppb Some Arsenic Uses/Anthropogenic Sources • Smelting of metals A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... No public clipboards found for this slide. Clinical Environmental Health and Toxic Exposures, Lippincott Williams & Wilkins; 2 edition (June 4 2001). loveland tech4good luke whitaker / may 27, 2014. arsenic detection techniques. References Caballero, B.(2009). small systems implementation strategy & exemptions. not anticipated! 33. Arsenic - . properties. What causes chronic arsenic poisoning? poisoning. As 33 74.99. There are more than 8,000 villages in Bangladesh where more than 80 percent tube-wells are arsenic • Metabolized to toxic form of As3+ , MMA(III) before entering cells • ADP forms ADP-arsenate instead of ATP; Glucose-6-Arsenate instead of G6P; Glyceraldehyde-3-arsenate instead of G3P. Arsenic poisoning, or arsenicosis, happens when a person takes in dangerous levels of arsenic. Arsenic is highly toxic in its inorganic form. properties. Those who survive arsenic trioxide poisoning may develop encephalopathy or severe peripheral neuropathies. USES: primarily in the production of glass and semiconductors, in wood and hide preservation, as an additive of metal alloys In the past arsenic was used as weed killer, rodenticide, in chemical warfare pigments and enamels. Absorption • Soluble and acidic arsenic compounds are readily absorbed in the stomach • Inorganic Arsenic compounds can also be sequestered on mucosal linings, leading to irritations and a concentration gradient that aids in the absorption of Arsenic compounds. 33. as arsenic 75. arsenic. What Dr Kaleem Khan Assistant Professor JNMCH 2. Arsenic poisoning acts on different metabolic pathways of glucose metabolism. morgan dunn stevie turner. ARSENIC POISONING A. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. 33 2,8,18,5 as arsenic 74.92160. electron diagram. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. atomic number is 33 atomic mass is 75 family: 15 nitrogen. It is highly toxic in its inorganic form.People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops, industrial processes, eating contaminated food and smoking tobacco.Long-term exposure to inor… Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Arsenic toxicity is a global health problem affecting many millions of people. (2011). Wayne State University School of Medicine [PDF Document]. Alsevier Inc. Rosen, B. Arsenic toxicity and methods of detection. Journal of Applied Toxicology. elment info. poisoning. Arsenic round the world: a review. Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. Arsenic poisoning 1. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Arsenic is a natural component of the earth’s crust and is widely distributed throughout the environment in the air, water and land. danger rangers video. arsenic - . dr esther tsang august 2011. case 1. Arsenic contamination of groundwater is a form of groundwater pollution which is often due to naturally occurring high concentrations of arsenic in deeper levels of groundwater. It is the common environmental toxicant and is found in soil, water, and air. two kinds of poisoning have been identified by the national safety, Poisoning - . arsenic poisoning in tube. Looks like you’ve clipped this slide to already. Arsenic has been used since 3000 BC. Cancer Research. A 47-year-old man had an episode of severe respiratory failure after acute intoxication with arsenic. atomic number:33 element symbol:as element name:arsenic atomic mass:75. seafood –, Poisoning - . It is a high-profile problem due to the use of deep tube wells for water supply in the Ganges Delta , causing serious arsenic poisoning to large numbers of people. arsenic is a solid, liquid , and a gas!. Your advice would be useful in perfecting our future slides. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. However, symptoms of chronic arsenic poisoning from ingestion of contaminated water are typically observed only after 10 or more years of exposure. Clipping is a handy way to collect important slides you want to go back to later. Arsenic poisoning in Bangladesh Fluorosis • Tooth discoloration and decay • Crippling skeletal damage Arsenicosis • Skin pigmentation changes and skin thickening (hyperkeratosis) • Cancer of … See our User Agreement and Privacy Policy. Arsenic Poisoning. If you continue browsing the site, you agree to the use of cookies on this website. He was admitted 5 h later. Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. poisoning. used : rat poison found: food, water. everyone reacts differently. Toxicology Letters 133:1-16 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C.J., Valko, M. (2010). Welcome to Click to edit Master subtitle style ARSENIC POISONING Click to edit Master subtitle style Amir Sadaula (01) Arjun Pandit (02) Bikas Puri (03) Bishwo Bandhu Pokharel (04) p.861-864. The three main sources of exposure are occupational exposure, natural contaminants of drinking water (from some deep water wells) and ancient Chinese medicinal remedies containing arsenic. chronic arsenic poisoning among workers (17). As 33 74.99. group 15, metalloid (category/group) germanium, gallium, it sublimates, Arsenic - . This a special article from Telugudoctors.co.in; Hope you find it useful and informative. prepared by muhammad hashim. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Arsenic. by, jeremy rubert. Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. summarized the environmental behaviour of arsenic, with particular emphasis on sources, distribution, and accumulation of arsenic in the Australianence of Arsenic Trade Show Treatment Options Overview The main considerations when selecting a treatment technology include: Water quality characteristics (including pH levels and initial concentrations of iron, As(III), and As Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. why is it called arsenic?. Chronic arsenic poisoning is due to repeated or continuous exposure to arsenic compounds, which leads to an accumulation of arsenic in the body. Guide to Nutritional Supplements. and signs of arsenic poisoning in human beings may increase with a de crease in arsenic level in the drinking water source. jonathan kernaghan. An element found in many natural sources, PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson Arsenic Poisoning PHM142H1-F October 9, 2013 Presented by: NirojanBalachandran SarangaSreeskantharajan Kimberly Stobo TianQi Wang, As 33 • 74.99 What is Arsenic • An element found in many natural sources • Many uses including: • Agriculture (Wood preservative) • Medicine (Arsenic trioxide treatment for certain leukemia) • Arsenic recognized as a carcinogen • Arsenic poisoning most commonly through sources such as contamination of groundwater • Many cases throughout the world, Sign and Symptoms • Headaches • Drowsiness • Diarrhea • Vomiting • Bloody urine • Convulsions • Changes in fingernail pigmentation (leukonychiastriata) • Coma  Death, How Arsenic Enters the Body • Mainly through inhalation and ingestion • To a lesser extent, through the skin • Enters cells via Aquaporin channels. – A free PowerPoint PPT presentation (displayed as a Flash Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. food sources. 6 th period by: katelyn keller brianna leslie tiffany goulart. | PowerPoint PPT (2013). food air water. peter worcester a period. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. The Scientific World Journal, 2013, 13 Pages. EvironmnetalChemistry.com. Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate Summary Exposure to heavy metals such as mercury, lead, iron, and arsenic is harmful to the human body and can potentially cause both acute symptoms (e.g., local irritation, gastroenteritis, and pneumonia) and longterm effects (e.g., abnormal physical development, cancer, damage to the central nervous system, and kidney). You can change your ad preferences anytime. We have tried to make it as attractive, brief and informative as possible. Slide 7- ppt slide no 7 content not found • Carcinogenic due to oxidative stress, inhibition of p53, genotoxicity, altered DNA repair mechanisms and tumor promotion • “Arsenite” - Trivalent (As3+): Reacts with reacts with thiols and sulfhydryl groups • Inhibits GSH Reductaseblocks of GSH production Oxidative stress and production of free radicals • Inhibits Pyruvate Dehydroxygenase decreased activity in Citric Acid Cycle decreased ATP production and Gluconeogenesis • “Arsenate” - Pentavalent (As5+): replaces phosphate groups because of similar molecular structure). Distribution • The largest quantity of arsenic is found in the liver. Features of the initial clinical presentation included nausea, vomiting, and diarrhea, acute psychosis, diffuse skin rash, and marked pancytopenia. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. as. substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . 2,8,18,5. information. Arsenic poisoning: A national health security issue Arsenic exposure in Bangladesh is widespread and it involves thousands of wells. Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). His blood picture and abdomen radiography were as in the images. Toronto: Oxford UP, 2009. 62:3893-3903 Mcintyre, D, O. Linton, T, K. (2011). Re-cently, Smith et al. +3. Furthermore, it was observed that new cases of human poisoning … Mandal, B. K., & Suzuki, K. T. (2002). Create stunning presentation online in just 3 steps. Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and Qi Wang, sarah plante, sammi pedigo we use your LinkedIn profile and activity to... Many traditional remedies Exposures, Lippincott Williams & Wilkins ; 2 edition ( June 4 2001 ) it. Telugudoctors.Co.In ; Hope you find it useful and informative can include skin lesions, limbs! That is found in soil, water is made by determining inorganic and organic of! Mass: 74.92 metalloid grey or yellow or black, poisoning - by kristin hoffpauer, courtney maccallum, plante! To go back to later acute psychosis, diffuse skin rash, and cognitive.... 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