What is a carcinogen?. • Animal studies directly induce cancer in test animals using a large sample of animals, usually of two or more species with varying dose and time parameters. • Local ventilation--exhaust (sometimes supply) at the point of use of a chemical. In early studies, it was observed that a long latent period could elapse from exposure to carcinogens to the development of cancer. • Epidemiological studies determine the relationship between a cancer suspect chemical and a human population over a long period of time. • Special solutions or solvents on hand if required for decontamination of skin, eyes. • Experiments with animals are based on the premise that chemicals that produce cancer in animals will have similar effects on human cells. Most known human carcinogens produce cancer in experimental animals. • It is listed under Group 1 (“carcinogenic to humans”) by the International Agency for Research on Cancer (IARC). • Medical monitoring may be required if it is anticipated that PELs may be exceeded. Personal protective equipment • Respiratory protection--dust masks, respirators. UV light causes a specific type of DNA damage, i.e., thymidine dimers (cyclobutane). • Waste bottles must be properly labeled, tightly capped at all times (except when adding or removing waste) and they must have secondary containment. Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. • Remove lab coat or other potentially contaminated protective clothing before leaving the work area. Training needed. • Do not allow inventories to accumulate. They include metals such as cobalt and nickel and crystals such as silica. 27 slides: Chemical Carcinogens Carcinogens are chronic toxins. • Mutagens have adverse effects on fertility and general reproductive performance. (Required in Lab Standard.) • Dry cleaning of surfaces and equipment must be done by vacuum systems with high-efficiency filters. Cells constantly deal with the formation of DNA adducts from either endogenous or exogenous influences (Greenfield et al., 1984; Hoeijmakers, 2009; Phillips et al., 2000), including DNA damage that occurs secondary to radiation. • Any discrete chemical compound which has been shown to cause cancer in human or animal studies. What organs to carcinogens attack? No mouth pipetting! 1988). Carcinogenic potency of some chemical carcinogens correlates with their binding level to • All contaminated floor sweepings, debris (paper towels, Kimwipes, plasticware), discarded filters from respirators or vacuums must be bagged, properly labeled and sent out for incineration. of the work of cco/octrf. They may have not immediate apparent harmful effects, with cancer developing only after a long latency period. • Respirator may be needed for spill cleanup. • Area monitoring may be required in some cases. What is an OSHA “select” carcinogen? ... Tar, which formed up to 1/3 of the chemical of soot, was the chief suspect. This may be done by EH&S staff. CTD: a resource for predicting chemical-gene-disease networks - . It may be a substance in the air, a product you use, or a chemical in foods and drinks. Neoplasia V Carcinogenesis - . • Eye protection--safety glasses, splash goggles, face shields. • Separated by shelving system or secondary containment. File Name: File Size: File Type: Chemical_Carcinogens_1.ppt: 101376: PPT File index.asp: 33067: ASP File The first of these is DNA repair (Hoeijmakers, 2009). • Biosafety cabinet--used for anticancer drugs, viruses. Related Chemical Safety Training Courses Chemical Protection Clothing Chemical Hygiene and Engineering Chemical Spill Chemical Safety Chemical Handling Chemical Carcinogens by Estonian OH&S Number of Slides:22 Created By:Estonian OH&S This training presentation was created by Estonian OH&S. Ionizing or ultraviolet radiation and most chemical carcinogens cause lesions in DNA. Chemical carcinogens may bind to DNA. • Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. Particulate matter includes a variety of different compounds that are naturally present as tiny particles. ...… what we know and don’t know about the relationships between exposure to certain. Respirators are primarily for use in non-lab areas, except for emergency response (spill cleanup)--shops, floor stripping, construction operations (painting). identify the drug that makes tobacco addictive. human carcinogens. Now customize the name of a clipboard to store your clips. A seminal breakthrough was Yamagiwa's production of skin tumors in rabbits by the direct application of coal tar in 1915, which led to the isolation, identification, synthesis, and biological testing of polycyclic aromatic hydrocarbons (PAHs) as chemical carcinogens, including dibenz[a,h]anthracene and … &Carcinogenic Agents. list 6 types of tobacco products. dec 3, 2008. carcinogens : there exists a “measurable” risk from any exposure, eg 4.1 x 10 -6, Chemical Changes - Presented by: bailey newbill. III.C Prevention of Carcinogenesis. • Spill mixtures and cleanup materials for spills on hand. Any substance that is capable of causing cancer.Any substance that is capable of causing cancer. introduction. • Fume hoods--full open face velocity of 8o to 100 l.f.p.m.. combined with a dry ice capture test. carcinogens. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. • All used spill cleanup materials must be treated as hazardous waste. Shigeki Tsuchida, in Encyclopedia of Cancer (Second Edition), 2002. Getting cancer from a chemical depends on the following: •The kind of chemical you were exposed to, •How much of the chemical you were in contact with, •How long the contact lasted, •How often you were exposed, chemical reactions involve a chemical change. • Purchase carcinogens in the smallest possible quantities. In 1941, Rous and Kidd painted the skin of rabbits and found that if this painting were interrupted, tumors would disappear only to reappear if the application of tar was re-estab… These induce GSTs and other drug-metabolizing enzymes, and their induction of GSTs closely correlates with their tumor inhibitory activity. • Any substance that is capable of causing cancer. If you continue browsing the site, you agree to the use of cookies on this website. Chemical Carcinogens 7. • Dry wastes must be incinerated or shipped out as regulated medical waste (“chemotheraputic agents”). • Radiation carcinogenesis. It lists the types, classification and labelling of carcinogens, along with workplace risk … Check “Poison” on the waste label. What are reproductive toxins? Swallowing of a carcinogen. Cancer is the abnormal or uncontrolled growth of new cells in any part of the body, characterized by cells that tend to invade surrounding tissue and metastasize to new body sites. Any substance that … • Locations where entry and exit or use of an area is restricted to the use of carcinogens. 1. CHEMICAL CARCINOGENS. The lower the dose the least likely you are to develop cancer or related diseases. Ionizing Radiation Ionizing radiation includes: X-rays, gamma rays, as well as particulate radiation; alpha, beta, protons, neutrons and primary cosmic radiation. chemical changes. CHEMICAL CARCINOGENSCHEMICAL CARCINOGENS 2. a chemical change is a, 3 ways of representing the reaction of H 2 with O 2 to form H 2 O - Reactants. Place no longer needed materials in a recycling program or dispose of as waste. chemical equations. Radiation carcinogenesis. The End “There are old researchers and there are bold researchers, but there are no old, bold researchers!” Anon. Use an “ALARA” policy. Examination by a physician, blood tests, etc. An SOP may be developed for an individual carcinogen, a process or a class of chemicals. chapter 10. chemical reactions and equations: basic concepts. How do I dispose of waste carcinogens? • Training--all employees using carcinogens must be trained in the recognition of the physical and health hazards associated with the carcinogens they are working with, methods to detect the presence or release of a carcinogen and ways to protect themselves from exposure to the carcinogens with which they are working. Training required. Chemical Carcinogens 1 - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Any substance that is capable of causing cancer. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. styrene regulatory update styrene california workshop october 28, Risk Assessment II - . 4. Recently much work has been done to express carcinogenic potency quantitatively as the daily dose that will result in cancer in 50% of test animals in long-term experiments (18 or 24 months, most of the life-span of a rat or mouse). How do I reduce my inventory and level of waste generation. • Cigarette smoking (co-carcinogen) • Alcohol consumption (co-carcinogen) • Diet--high fat consumption, natural antioxidants • Geographic location--industrial areas, UV light • Therapeutic drugs--some are known carcinogens • Inherited conditions, How do I reduce my exposure to carcinogens? Most carcinogens and mutagens are strong electrophilic reactants. • Detoxify carcinogens as part of your research protocols. Any substance that is capable of causing cancer. carolyn mattingly north carolina state university. Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? chapter 21: chemical reactions. What is a chemical carcinogen? • Environmental or “lifestyle” factors. Follo wing exposure, chemical carcinogens may be ab- sorbed in a number of ways (oral, inhalator, cutaneous, and injection) and distributed across several tissues (Con- ... Ionizing radiation Natural products (progesterone, safrole) ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 783f26-NjRkM tiina santonen 4.11.03 paide. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. • Any “incidental” spill may be cleaned up by the lab staff; larger spills may require a emergency response (5-1111). • Dry sweeping or compressed air cleaning of floors or work surfaces is prohibited. Common Carcinogens You Should Know. What materials are carcinogens? 6. a carcinogen is any substance, radionuclide, Carcinogenesis - . ), Which classes of chemicals tend to be carcinogens? chemical change = chemical reaction a chemical equation is a, 2.6 Chemical Equations - A chemical equation is the symbolic representation of a chemical reaction in terms of chemical. They cause damage after repeated or long-duration exposure. They may have not immediate apparent harmful effects, with cancer developing only after a long latency period. name six dangerous. 9. Lab coats need to be cleaned regularly; special washing instructions may be needed. What dictates this outcome is relatively predictable but highly variable. What factors influence the development of cancer? • Employees must be trained in the content of the SOP. • Viral oncogenesis. organic compounds: Formaldehyde Acetaldehyde 1,4-DioxaneEthyl carbamate 2-Nitropropane Styrene Thiourea Thioacetamide • Misc. 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